The RNA editing enzyme ADAR1 seemingly has more functions besides RNA editing. Mouse models lacking ADAR1 and sensors of foreign RNA show that RNA editing by ADAR1 plays a crucial role in the innate immune response. Still, RNA editing alone cannot explain all observed phenotypes. Thus, additional roles for ADAR1 must exist. Binding of ADAR1 to RNA is independent of its RNA editing function. Thus, ADAR1 may compete with other RNA-binding proteins. A very recent manuscript elaborates on this and reports (...) competition of ADAR1 with STAUFEN1, thereby modulating RNA-degradation. ADAR1 is also known to recruit proteins such as DROSHA to nascent transcripts. Still, many open questions remain. For instance, the biological role of the Z-DNA binding domains in ADAR1 is not defined. Moreover, the impact of ADAR1 on the RNA-folding landscape is unclear. In sum, moonlighting functions of ADAR1 may be manifold and have a great impact on the transcriptome. Adenosine to inosine RNA editing by ADAR1 is mostly known for its role in the innate immune response to help discriminate self from non-self RNA. Here we discuss the other face of ADAR1 that impacts on cellular processes independent of its editing function. These include Staufen-mediated-decay, mRNA processing, or miRNA maturation. (shrink)

Michael Palmer provides a detailed account of two of the most important theories of religion in the history of psychology--those of Freud and Jung. The book first analyzes Freud's claim that religion is an obsessional neurosis, a psychological illness fueled by sexual repression. He then considers Jung's rejection of Freud's theory, and his own assertion that it is the absence of religion, not its presence, which leads to neurosis.

Michael F. Duggan ABSTRACT: This article examines the basis for testing historical claims and proffers the observation that the historical method is akin to the scientific method in that it utilizes critical elimination rather than justification. Building on the critical rationalism of Karl Popper – and specifically the deductive component of the scientific method called ….

Recently several philosophers have argued that environmental reform movements cannot halt humankind’s destruction of the biosphere because they still operate within the anthropocentric humanism that forms the root of the ecological crisis. According to “radical” environmentalists, disaster can be averted only if we adopt a nonanthropocentric understanding of reality that teaches us to live harmoniouslyon the Earth. Martin Heidegger agrees that humanism leads human beings beyond their proper limits while forcing other beings beyond their limits as weIl. The doctrine of (...) the “rights of man” justifies human exploitation of nonhuman beings. Paradoxically, however, the doctrine of rights for nonhuman beings does not escape the orbit of humanism. According to Heidegger, a nonanthropocentric conception of humanity and its relation to nature must go beyond the doctrine of rights. We can dweIl harmoniously on Earth only by submitting to our primary obligation: to be open for the Being of beings. We need a new way of understanding Being, a new ethos, that lets beings manifest themselves not merely as objects for human ends, but as intrinsically important. Heidegger calls this ethos the “fourfold” of earth and sky, gods and mortals. Humanists argue that Heidegger is wrong to abandon the principle of human rights in favor of the notion that we are obligated to “let beings be,” while some radical environmentalists accuse hirn of being a humanist because he supposedly overestimates the importance of humankind’s ability to speak. Heidegger insists, however, that language makes possible culture, without which thereis no human experience of nature. An environmentally sound ethos. can arise, according to Heidegger, only from a shift within the cultural heritage of the West. Richard Rorty agrees that we must become open for a new “conversation” with the West, even if this requires abandoning traditionally important fields such as epistemology. The need to develop a new understanding of Being is so great that thinkers from the analytic and continental traditions of philosophy are finally initiating a long-overdue dialogue. (shrink)

Aims to rethink ethics and transcendence in light of the phenomenology of empathy and social ontology.

Berichte zur Wissenschaftsgeschichte, Volume 45, Issue 3, Page 434-451, September 2022.

Adopting temporal parts theory is the most popular way of addressing a host of puzzles about diachronic identity. For example, it is not obvious how I am the same person as the baby who shared my name. With the theory, sameness of person, e.g., consists in being comprised by the same temporally extended, four-dimensional object. However, temporal parts theory has unacceptable consequences for notions of freedom and probability. I show that the only acceptable reading of four-dimensionalism entails that the four (...) dimensional object that is me, say, already exists in its entirety. This entails that all of my future properties are already set. This nearly Spinozistic result robs us of familiar notions of choice and possibility. I argue that these notions are more central to our thinking than temporal parts theory, and that on these grounds we must look elsewhere for solutions to our questions about identity across time. (shrink)

ABSTRACT The destruction of the environment is a matter for moral concern and cannot be halted in the long term by appeals to human utility. However, the inadequacy and naïvety of humanist styles of ethical argument become apparent when attempts are made to extend them to environmental issues. They usually abstract certain supposed features of natural objects, e.g. sentience, and reify these as essential characteristics which operate to carry or ground ethical values. These arguments necessarily lead to the exclusion of (...) objects which are, in fact, ethically valued or entail an unacceptably expansive egalitarianism. Such egalitarianism is often followed by a return to human‐centred prejudices opposed to the originally stated aims of ‘biocentric’ethicists like Taylor. Similarly, those physical and ecological holisms which rely not upon shared ‘natural’features, but upon sharing in nature itself cannot solve this dilemma as they are incapable of explaining differential ethical values. The attempt to place boundaries on moral considerability should be abandoned in favour of an ethical pluralism which places emphasis on the context of valuations. (shrink)

Wilkinson (1991) suggests that the problems of polarity decisions and homoplasy in a cladistic analysis may be solved if cladists simply accept plesiomorphy as a reliable indicator of monophyly. Here we argue that: (1) Wilkinson's argument is based on misapprehension of synapomorphy and the problem of homoplasy; (2) His proposed methodology fails to consider the full ramifications of rooting, polarity, and parsimony; and (3) His method does not solve the problems he raises. We demonstrate the limitations of this methodology by (...) using Wilkinson's practical example. We find no justification for the assertion that plesiomorphy may reliably delimit monophyly and recommend against Wilkinson's suggested methodological revisions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:On Japanese Things and Words:An Answer to Heidegger's QuestionMichael F. MarraIt has been over thirty years since my high school teacher of philosophy, Professor Dino Dezzani, recommended a book from which to begin my study of philosophy: Martin Heidegger's (1889-1976) Unterwegs zur Sprache (On the way to language [1959]). Evidently he was aware of my interest in literature and thought that Heidegger's discussion of words, things, and poetic language (...) would give some sort of direction to my naïve and youthful questions of what literature is about and what I should hope to find in it.The impact that Heidegger's book had on this young student was much greater than my professor could ever have imagined. I would hardly have committed myself to the study of Japan were it not for my reading of "A Dialogue on Language between a Japanese and an Inquirer," which appears in On the Way to Language. The dialogue is a fictional reconstruction of an actual meeting that Heidegger had with Tezuka Tomio (1903-1983), a Japanese scholar of German literature who visited the German philosopher in Freiburg at the end of March 1954.1 In the dialogue the Inquirer (Heidegger) formulates a central question that, in my opinion, should be of fundamental interest to anyone seriously concerned with the study of Japan. The question is deceptively simple, at least compared with the difficulty of coming up with the answer-an answer that, as a matter of fact, the reader will not find fully formulated in the dialogue. The question is: "What is the Japanese word for 'language' "? The Japanese visitor (Tezuka in Heidegger's recollection) appears to have been caught off guard, as we can see from Heidegger's parenthetical remark: "after further hesitation." Had Heidegger posed the same question to a Frenchman or an Italian, the answer would have been immediate: "langue" or "lingua." The challenge for Tezuka was definitely higher since he had a variety of words from which to choose. He could have used, for example, the expression gengo, a combination of two Chinese characters indicating "the speech of words." Instead, he used an ancient Japanese word derived from the native Yamato vocabulary: kotoba, which literally means "the foliage of speech."2There should be little doubt that Tezuka's choice was prompted by his desire to please Heidegger by playing the philosopher's own game-something that Tezuka totally succeeded in doing, as Heidegger's dialogue attests. Tezuka introduced a term that lent itself to etymological play-an enterprise very close to the heart of Heidegger, and one that was also very popular among Japanese thinkers.3 In fact, the expression kotoba incorporates the word koto, which means both "thing" and [End Page 555] "word" and which is found in the basic concepts of Japanese ontology: Mikoto (God, or "the honorable thing"), makoto (truth, or "the true word"), kotodama (soul, or "the spirit of words"), and kotowari(reason, or "the splitting of things"). The association of "words" and "things" in the Japanese word for "language" must have been of particular interest to Heidegger, who, four years before his meeting with Tezuka, had written "Das Ding" (The thing), a major lecture on the notion of things interpreted in light of the fourfold earth, sky, divinities, and mortals. In the dialogue Heidegger refers to this essay, in which "things" are presented in their objectified presence-the disparaged things that modernity and technology have dispossessed of their Being (Sein). Heidegger points out that never has the distance between things and Sein been as great as in modernity, when all distances in space and time have shrunk.4 Given the unflattering position that Heidegger had taken on the notion of "things," Tezuka was forced to come to the rescue of the Japanese word kotoba by endowing koto with the meaning of two Heideggerian keywords: "event" (kotogara) and "affair" (Sache). The thingly component of kotoba was not simply an objectifiable presence that can be counted, analyzed, and disposed of, but rather a poietic "act" that has the power to create a reality by transforming the named thing (koto) into a real thing (koto).In "A Dialogue... (shrink)

Introduction There has been philosophical discussion for centuries on the nature and scope of human life. Lucretius, for example, contends that human life ...

All species continuously evolve to adapt to changing environments. The genetic variation that fosters such adaptation is caused by a plethora of mechanisms, including meiotic recombination that generates novel allelic combinations in the progeny of two parental lineages. However, a considerable number of eukaryotic species, including many fungi, do not have an apparent sexual cycle and are consequently thought to be limited in their evolutionary potential. As such organisms are expected to have reduced capability to eliminate deleterious mutations, they are (...) often considered as evolutionary dead ends. However, inspired by recent reports we argue that such organisms can be as persistent as organisms with conventional sexual cycles through the use of other mechanisms, such as genomic rearrangements, to foster adaptation. (shrink)

This paper compares Plotinus’s neoplatonic conception and account of time with Bergson’s and Husserl’s phenomenologic conceptions and accounts of it. I argue that despite fundamental differences owing to their respective approaches, their conceptions and accounts are remarkably comparable, especially in considering time to play a fundamental role in the organic unity of our physical environment—in what I characterize also as the continuously and intrinsically connected sequentiality of its events, processes, and constituents—in Plotinus’s case, of our physical environment as such; in (...) Bergson’s and Husserl’s case, as it manifests itself to us in experience and our reflective awareness of that experience. (shrink)

Original essays by leading scholars on Plotinus' philosophy of nature.

This series of interpretations of selected classics examines premodern Japanese literature from the perspective of conflictual ideologies. Professor Marra's analysis of such works as the Ise Monogatari, the Hojoki, and Tsurezuregusa highlights the existence of discontent in the authors of the so-called high tradition and explains the means these authors used to express their social dissatisfaction in literary texts. His aim is to recover the validity of the historicist approach in literary studies by focusing on the importance of the context (...) in the formation of the text. The text is seen as a product of ideological manipulation on the part of those who, by reading, writing or editing, appropriate it according to specific and private concerns. Professor Marra displays both sensitivity to the texts and a comprehensive grasp of Japanese and Western scholarship in making his argument that aesthetics and politics in premodern Japanese literature are mutually defining. (shrink)

William Newcomb and Robert Nozick have provided us with the following problem in rational decision-making. There are two boxes, A and B. A contains either a million dollars or nothing. B contains a thousand dollars. I come into the room in which we have the boxes, closed. I must make one of two choices. Either I open A and take whatever money is present, M or O, or I open both and take whatever money is present, M + T or (...) O + T. What is the rational choice for me to make?Nothing unusual is meant by “rational” in this context. We assume that a person making the choice desires as much money as possible. We assume that he will take into account all relevant available information as to what decision will lead to more money. If he believes that doing X will, or is likely to, lead to more money than doing not-X, then he will do X.In the above case, it would seem that the rational choice is both. T is there for the taking, whether or not I get M, and I might as well try for both. (shrink)

Mendelian Inheritance in Man, a computerized catalogue of human genetic disorders authored and maintained by cardiologist and medical genetics pioneer Victor A. McKusick, played a major part in demarcating between a novel biomedical science and the eugenic projects of racial betterment which existed prior to its emergence. Nonetheless, it built upon prior efforts to systematize genetic knowledge tied to individuals and institutions invested in eugenics. By unpacking the process of digitizing a homespun cataloguing project and charting its development into an (...) online database, this article aims to illuminate how the institution-building efforts of one individual created an ‘information order’ for accessing genetic information that tacitly shaped the norms and priorities of the field toward the pursuit of specific genes associated with discernible genetic disorders. This was not by design, but rather arose through negotiation with the catalogue's users; it accommodated further changes as biomedical research displaced the Mendelian paradigm. While great effort was expended toward making sequence data available to investigators during the Human Genome Project, MIM was largely taken for granted as a ‘legacy system’, McKusick's own labour of love. Drawing on recent histories of biomedical data, the article suggests that the bibliographical work of curation and translation is a central feature of value production in the life sciences meriting attention in its own right. (shrink)

The authors attempt to prove that single energy arrays cannot specify reality. We offer contrary evidence that motion structures the acoustic array to specify fundamental attributes of the source. Against direct detection in general, we cite evidence that humans weight acoustic inputs differentially when making perceptual judgments of auditory motion.

Michael Walzer is currently at the School of Social Science, Institute for Advanced Study, in Princeton, New Jersey. Professor Walzer has written Just and Unjust Wars; The Revolution of the Saints and has edited Toward A Global Civil Society. In this interview, he discusses some of the current concerns about education, political theory and the current state of the art of toleration, and acceptance and accommodation of different racial, ethnic, social and minority groups. He has published extensively and his (...) work has been translated in several other languages. In this interview, he responds to questions about his work, his writings and his current concerns. (shrink)

Schober et al. describe two studies on how survey interview respondents misunderstand interview questions. After answering a survey, participants are given standardized definitions of the questions they have just answered. Even apparently simple questions such as “Have you smoked more than 100 cigarettes?” are interpreted very differently by participants. Moreover, clarifying the meaning of the definitions with the interviewer does not always help resolve the miscommunication.

ABSTRACTIs it possible to reconcile the concept of conscious agency with the view that humans are biological creatures subject to material causality? The problem of conscious agency is complicated by the tendency to attribute autonomous powers of control to conscious processes. In this paper, we offer an embodied process model of conscious agency. We begin with the concept of embodied emergence – the idea that psychological processes are higher-order biological processes, albeit ones that exhibit emergent properties. Although consciousness, experience, and (...) representation are emergent properties of higher-order biological organisms, the capacity for hierarchical regulation is a property of all living systems. Thus, while the capacity for consciousness transforms the process of hierarchical regulation, consciousness is not an autonomous center of control. Instead, consciousness functions as a system for coordinating novel representations of the most pressing demands placed on the organism at any given time.... (shrink)

The controversy over the meaning and parameters of Franciscan poverty is one of the most widely discussed issues in medieval historiography, both within the Franciscan order as well as outside of it, both during the Middle Ages as well as among contemporary scholars even today. Contemporary scholars—be they professed Franciscans or professional Franciscanists—have generally shown an interest in reconstructing the evolution of the friars' practice of their poverty and the debates about this subject that were raging within the order among (...) the friars themselves as well as between the order and their critics outside of it. These scholarly efforts have followed the trajectory of a more classically historical approach.... (shrink)

Part I: Dimensions of time's enigma -- Is time real? -- Eleaticism, temporality, and time -- The makings of a temporal universe -- Pastness and futurity -- Synchronicity and synchronicity -- Temporal pace and measurement -- Presentness or the present -- Aristotle's real account of time -- Parmenidean time and the impossible now -- Cosmic motion and the speed of time -- Time as the motion of the cosmos -- Time as the cosmos itself -- Time as motion and all (...) change -- Temporal cognition and the return of the now -- Real temporality in an Aristotelian world -- Does Aristotle refute eleaticism? -- Bisection argument I -- Bisection argument II -- Bisection argument III -- Plotinus' vitalistic platonism and the real origins of time -- Temporality, eternality, and Plotinus' new metaphysic -- Plotinus' critique of Aristotelian motion -- Indefinite temporality and the measure of motion -- Plotinus' neoplatonic account of time. (shrink)

Individuals do not operate “at a stage of development.” They operate at a range of different levels of hierarchical complexity depending on skill area, task, context, degree of support, and other variables. It is thus necessary to postulate the concept of domain to refer to the particular conceptual, behavioral, or affective area within which activity operates. The concept raises questions and implications for theory building and application. Such issues are elaborated by discussing a variety of domains and social contexts. A (...) postformal case example of leadership in higher education illuminates the concept of domains and the interrelationships among domains. (shrink)